The I.S.S. Sisko is an Odyssey-class Dreadnought and a flagship of the Terran Empire's invasion forces during their second invasion of the prime universe. The Sisko is equipped with technology to create and maintain trans-dimensional portals, possibly based on information gleaned from the Orb of Possibilities.
- “Mirror Universe Incursion”: The Sisko is the command ship of the Terran fleet invading the prime universe and attacking Vauthil Station.
- The Sisko is likely named after Benjamin Sisko.
- The Sisko is one of several possible dreadnoughts that may lead the final wave of Imperial ships.