- See article: "Infected: Manus" Walkthrough
Instead of walking, Manus hovers above the ground, meaning she can very quickly move between platforms and that she cannot simply be pushed into the plasma.
- “Fluid Dynamics”: Captain Rebecca Simmons commands the U.S.S. Venture as part of a joint task force sent to eliminate the Borg presence in Fluidic Space; Captain Simmons goes missing when the ship is attacked by the Borg.
- “Infected: Manus”: Rebecca Simmons, having visited Starbase 82 as a representative of the Borg Task force, has been assimilated by the Borg. In an effort to use the assimilation counter-agent developed on Omicron Kappa II, she had descended alone into the Borg-occupied levels of the station. Renamed Manus of Borg, she taunts the players as they progress through Starbase 82, before finally confronting them at the center of the station.
- “Khitomer in Stasis”: The player's crew notes that Manus was an example of a "modern" Borg drone which demonstrated a capacity for independent thought.
- There is a continuity error regarding Simmons. While she goes missing following an encounter with the Borg in “Fluid Dynamics”, Commander Pan in “Infected: Manus” states that she had visited Starbase 82 as a representative of the Borg Task Force, and was assimilated after her arrival.
- Manus is Latin for "hand", likely a reference to the Borg faction icon resembling a stylized hand.
- She is voiced by Maria Rosseau.