Opaka was born on Bajor during the occupation and became a revered figure among her people. Opaka was the first to identify Benjamin Sisko as the Emissary of the Prophets and gave him an orb that led to the discovery of the Bajoran Wormhole. ("Emissary")
Opaka asked to travel through the wormhole and encouraged Sisko (accompanied by Kira Nerys and Julian Bashir) to investigate a moon of the Olt System in the Gamma Quadrant. On arrival, the moon's satellite grid attacked the runabout, causing it to crash on the surface. Opaka ostensibly died on impact, but was later revived by artificial microbes on the planet. ("Battle Lines", “Armistice”)
The microbes had been designed to keep two warring groups of prisoners (the Ennis and the Nol-Ennis) alive. However, once revived the body becomes dependent on the microbes meaning Opaka and the prisoners could not be evacuated without killing them. Opaka remained as the crew left, hoping to bring peace between the two warring groups. ("Battle Lines")
- “Armistice”: Kai Kira has secured a cure for the microbes from the Dominion, who obtained it from the people who established the prison. Kira, Bashir and the player go to retrieve Opaka and the prisoners before they fall victim to the Hur'q.
- “Home”: The player speaks with Opaka, who has resumed her role as Kai, in the Bajoran temple on Deep Space 9. She explains that the Orb of Peace, which was brought back from the Gamma quadrant with her, gave a vision to Loriss and believes this to be a sign that the Orb is intended to broker long-term peace between the powers of the Alpha, Beta, and Gamma quadrants.
- The U.S.S. Opaka, named in honor of the Kai, aids the defense of Deep Space 9 during “Second Wave”.
- For players who have completed “Armistice”, Opaka can be found near the orb in the Bajoran temple in Hathon.